|
KMID : 0613820090190050688
|
|
Journal of Life Science
2009 Volume.19 No. 5 p.688 ~ p.691
|
|
|
Cognition Enhancing Effect of Muskmelon (Cucumis melo) Extracts on Scopolamine-induced Memory Impairment in Mice
|
|
Park Sang-Shin
Park Naomi
Kang Ju-Uk
Shin Suk-Chul
Lee Dong-Ung
|
|
|
Abstract
|
|
|
|
The methanol extract of muskmelon (Cucumis melo) has been investigated for its cognition enhancing effects by evaluation of inhibitory activities on acetylcholinesterase, a degrading enzyme of acetylcholine, a brain neurotransmitter, and β-secretase, which forms the β-amyloid toxic protein from its precursor protein. A passive avoidance task, one of the animal model experiments for learning and memory, was also performed. As a result, the melon extract showed 15.8% and 35.3% inhibition on acetylcholinesterase and β-secretase, respectively, with a final concentration of 100 ㎎/ml. In the animal model test, melon extract significantly (p＜0.05) lengthened the step-through latency time by 22.7% compared to the control group, suggesting that melon extract has, indeed, an effect on cognition enhancement.
|
|
|
KEYWORD
|
|
|
Cucumis melo, cognition, acetylcholinesterase, β-secretase, passive avoidance task
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|